| "+
" "+
"Having accumulated four years’ experience of high altitude research at Monte Rosa (Hut Regina Margherita,"+
"4559 m a.s.l.), Istituto Auxologico Italiano (Ospedale S. Luca, Milano, Osp. S. Giuseppe, Piancavallo, Verbania) and University of Milano-Bicocca (Dept. of Clinical Medicine and Prevention) organize an expedition in the Mount Everest area on the Chinese/Tibetan side, aimed to assess the physiological changes induced by the exposure to more marked and more prolonged hypobaric hypoxia and to determine how these changes may be influenced by angiotensin AT1 receptor blockade by telmisartan and by other non-pharmacological interventions.
"+
"During the expedition most participants will reach altitudes higher of 6000 m a.s.l. (Advanced Base Camp 6400 m a.s.l.), while a subgroup of alpinists will attempt an ascent to Mt. Everest summit (8848 m a.s.l.).
"+
"Most of the physiological changes occurring at high altitude are due to decreased atmospheric pressure leading to hypoxia and hypoxemia. The study of the high altitude exposure is important because it allows a better understanding of the mechanisms of adaptation to high altitude and of acute mountain sickness (AMS) but also because this condition may serve as a model of diseases associated with tissue hypoxia, such as heart failure, chronic obstructive pulmonary disease, sleep apnoea syndrome, or severe obesity."+
" " +
" | " +
"
" +
"